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Dear Dr. [FIRSTNAME]

As a researcher you are often required to distinguish the special form of a protein (mutated, proteolyzed, alternatively spliced, or post-translationally modified) from its normal counterpart. For this purpose, antibodies would be raised against a short sequence that contains a specific site of alteration or modification. We are well aware of the technical difficulties and high cost that you might face in this process. We are thus pleased to introduce the new SEAL FOCUS libraries with the twin goals of lowering your investment and maximizing your chance of success.

Using the special SEAL technology, our custom monoclonal antibody service would provide you:
1) multiple antibodies (6-20) raised against multiple epitopes (4-12) of the same protein, thus greatly enhancing your chance of success;
2) antibodies which bind your targets with nanomolar affinity;
3) antibodies that recognize both the native and the denatured state of your protein;
4) antibodies of known epitope
Different from the traditional "trial-and-error" research-like antibody development practices, SEAL technology employs multiplexed antigens, multiplexed immunizations, multiplexed fusions and multiplexed cell line selections to guarantee the yield of a library of high affinity monoclonal antibodies against multiple independent epitopes of a target protein. Together, the SEAL library approach is tens of times more successful to produce antibodies for a single antigen, and can be more than one hundred times more successful for a protein target when multiple antigens are used. From such a diverse SEAL library, you are far more likely to discover successful antibodies for a variety of applications.
Hundreds of scientists have published papers which cite the use of our custom monoclonal antibodies. Below are a few

Journal Antigen Description of the antigen Application
Cell
144,341-52		 phospho-ACF Phosphospecific-ACF(a > 500 kDa microtubule-actin crosslinking protein) WB
J Biol Chem.
288,23252-63 		phospho-Thr-55 specific SHP phospho-Thr-55 specific SHP(Small heterodimer partner) WB
The Plant Cell
21,1607-19		 Phosphoserine237 SCaBP8 phosphoserine237 sos3-like calcium binding protein8 WB
Mol. Cell
39,71-85		 me-Reptin Reptin(a chromatin-remodeling factor) methylated at lysine 67 WB
Biochem J
5,219		 phospho-PSD Tyr(523)-phosphorylated-postsynaptic density WB

                   >>Visit our website for more detail <<

You may consider the following services to develop antibodies for your research.
For Modified Protein For Protein
　 Our service other company service 　 Our service other company service
antigen 2 peptides 1 peptide antigen 6-12 Peptides+1 protein 1-2 peptides/protein
antibody 3-6 1-2 antibody 14-20 3-5
quality Modified Peptide ELISA titer>100K;
Control Peptide ELISA titer<10K   		 ELISA titer>20K; quality ELISA titer>100K;   ELISA titer>20K;
time <13 weeks(pAb)
<22 weeks(mAb)
 15-26 weeks time <20 weeks 21-26 weeks
cost ★★ ★★★★ cost ★★★ ★★★★★★

We wish you good success with your research and look forward to hearing from you.

Best wishes,

Julie Li Zhu, PhD
Custom Antibody Consultant,
A_b_m_a_r_t Inc.
Backup email: julie.li.zhu@hotmail.com
Phone: +86 21 3469 5916
Cell: +86-1502 1360 178
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